ABSTRACT
The problem of using contaminated food with toxigenic fungi is still one of the most important stigmas in the field of nourishment of human and animals. Aflatoxins are one of the toxigenic fungi that draw attention for researcher. This study was designed to determine how Aflatoxins contaminated food and feeding regimen might effect and induce specific changes in the muscle. Aflatoxins producing fungi were isolated from seed samples according to method of Shotwell et al. Spore suspension were prepared according to Faraj method. Rats were fed daily with diet contaminated with the spore. The Extensor digitorum longus muscle were removed and cut into small pieces incubated in Tetrazolium solution [NBT] incubation solution. The specimens were prepared and examined by electron microscope. Animals treated with AFB[1] have shown a marked increase in body weight Haziness and loss of the banding pattern of the sarcomers was a marked feature Reaction product of succinat-dehydrogenase showed increase reaction in treated animals at the site if mitochondria. Skeletal muscle nuclei showed a pronounced effect of Aflatoxins on the nuclei, they have become pyknotic and there number were less than normal. It has been concluded that AFB[1] have a marked effects on the structure of the sarcomere and on the activity of succinic dehydrogenase enzyme of the mitochondria